Инд. авторы:	Lvova M.N., Shevelev O.B., Serdobintseva V.V., Kalinin D.V, Starostenko D.A., Zavjalov E.L., Krivoshapkin A.L., Logachev P.V., Mordvinov V.A., Avgustinovich D.F.
Заглавие:	Effect of Silicon Dioxide Nanoparticles on Syrian Hamsters Infected by Opisthorchis felineus: H-1 MRS Study of the Brain
Библ. ссылка:	Lvova M.N., Shevelev O.B., Serdobintseva V.V., Kalinin D.V, Starostenko D.A., Zavjalov E.L., Krivoshapkin A.L., Logachev P.V., Mordvinov V.A., Avgustinovich D.F. Effect of Silicon Dioxide Nanoparticles on Syrian Hamsters Infected by Opisthorchis felineus: H-1 MRS Study of the Brain // Doklady Biochemistry and Biophysics. - 2020. - Vol.495. - Iss. 1. - P.319-324. - ISSN 1607-6729. - EISSN 1608-3091.
Внешние системы:	DOI: 10.1134/S1607672920060095; PubMed: 33368043; WoS: 000602077200011;
Реферат:	eng: In recent years, silicon dioxide nanoparticles have been widely used in medicine and the pharmaceutical industry, however, their effect on the brain has hardly been studied. We assessed the effects of long-term consumption of 5-nm amorphous silicon dioxide nanoparticles (SiO2-NPs) by Syrian hamsters infected with the trematodes Opisthorchis felineus on the hippocampus and frontal cortex. Spectroscopic determination of brain neurometabolites, performed using a horizontal Magnetic Resonance Imaging system at 11.7 Tesla magnetic field, has shown that the ratio of the excitatory neurotransmitters (glutamate + glutamine + aspartate) to the inhibitory ones (GABA + glycine) was higher in the animals infected with O. felineus. However, pre-consumption of the SiO2-NPs solution prevented this imbalance. In addition, the protective effect of SiO2-NPs on the level of myo-inositol and glycine was found. It is concluded that the use of SiO2-NPs can neutralize the negative effects of infectious factors on the brain.
Ключевые слова:	brain; MAGNETIC-RESONANCE-SPECTROSCOPY; nanoparticles; amorphous silica; Opisthorchis felineus;
Издано:	2020
Физ. характеристика:	с.319-324