| Инд. авторы: | Gulevich A.V., Koroleva L.S., Morozova O.V., Bakhvalova V.N., Silnikov V.N., Nenajdenko V.G. |
| Заглавие: | Multicomponent synthesis of artificial nucleases and their RNase and DNase activity |
| Библ. ссылка: | Gulevich A.V., Koroleva L.S., Morozova O.V., Bakhvalova V.N., Silnikov V.N., Nenajdenko V.G. Multicomponent synthesis of artificial nucleases and their RNase and DNase activity // Beilstein Journal of Organic Chemistry. - 2011. - Vol.7. - P.1135-1140. - ISSN 1860-5397 . |
| Внешние системы: | DOI: 10.3762/bjoc.7.131; PubMed: 21915218; WoS: 000294043500001; |
| Реферат: | eng: The synthesis of new, artificial ribonucleases containing two amino acid residues connected by an aliphatic linker has been developed. Target molecules were synthesized via a catalytic three-component Ugi reaction from aliphatic diisocyanides. Preliminary investigations proved unspecific nuclease activity of the new compounds towards single-stranded RNA and double-stranded circular DNA.
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| Ключевые слова: | CLEAVAGE; RIBONUCLEASES; UGI REACTION; RNA; DESIGN; organocatalysis; multicomponent reaction; isocyanide; DNA; peptidomimetic; HYDROLYSIS; |
| Издано: | 2011 |
| Физ. характеристика: | с.1135-1140 |