Инд. авторы:	Fursenko D.V., Khotskin N.V., Kulikov V.A., Kulikov A.V.
Заглавие:	Behavioral phenotyping of mice deficient in the tumor necrosis factor
Библ. ссылка:	Fursenko D.V., Khotskin N.V., Kulikov V.A., Kulikov A.V. Behavioral phenotyping of mice deficient in the tumor necrosis factor // Russian Journal of Genetics: Applied Research. - 2016. - Vol.6. - Iss. 4. - P.400-404. - ISSN 2079-0597. - EISSN 2079-0600.
Внешние системы:	DOI: 10.1134/S2079059716040067; SCOPUS: 2-s2.0-84975729823;
Реферат:	eng: The tumor necrosis factor (TNF) is a cytokine exerting both homeostatic and pathophysiological roles in the central nervous system (CNS). It has been demonstrated that TNF plays roles in diseases such as Alzheimer’s disease, Parkinson’s disease, and multiple sclerosis. Nevertheless, the roles of TNF in the CNS under normal physiological conditions have been poorly studied. A novel mouse strain with the TNF deficiency (TNFKO) was developed in S.A. Nedospasov’s laboratory at the Engelhardt Institute of Molecular biology of the Russian Academy of Sciences in a C57Bl/6 (WT) background. In our study, we compared the behavior of TNFKO and WT adult mice in a battery of tests: open field, elevated plus-maze, and the forcedswim test. We showed that TNF deficiency had no effect on locomotor activity or exploration in the openfield test. At the same time, in this test, TNFKO mice spent more time in the center of the arena, but had a higher level of defecation and lower rearing duration. This result indicates that, in the open-field conditions, TNFKO mice show disorientation rather than anxiety-like behavior. There were no differences between TNFKO and WT in the anxiety level in the elevated plus-maze test or in depressive-like behavior in the forced-swim test. These data suggest that the TNF deficiency leads to changes in neurofunctional interactions that alter the mouse’s response to mild stress in the open-field test. © 2016, Pleiades Publishing, Ltd.
Ключевые слова:	open field test; phenotype; priority journal; rearing; stress; mouse; male; locomotion; forced swim test; elevated plus maze test; disorientation; defecation; controlled study; Article; animal experiment; animal behavior; adult; tumor necrosis factor; tumor necrosis factor; open-field; knockout mice; forced-swim test; nonhuman; elevated plus-maze;
Издано:	2016
Физ. характеристика:	с.400-404