Инд. авторы:	Galanzha E.I., Weingold R., Nedosekin D.A., Sarimollaoglu M., Nolan J., Harrington W., Kuchyanov A.S., Parkhomenko R.G., Watanabe F., Nima Z., Biris A.S., Plekhanov A.I., Stockman M.I., Zharov V.P.
Заглавие:	Spaser as a biological probe
Библ. ссылка:	Galanzha E.I., Weingold R., Nedosekin D.A., Sarimollaoglu M., Nolan J., Harrington W., Kuchyanov A.S., Parkhomenko R.G., Watanabe F., Nima Z., Biris A.S., Plekhanov A.I., Stockman M.I., Zharov V.P. Spaser as a biological probe // Nature Communications. - 2017. - Vol.8. - Art.15528. - ISSN 2041-1723.
Внешние системы:	DOI: 10.1038/ncomms15528; PubMed: 28593987; WoS: 000402867400001;
Реферат:	eng: Understanding cell biology greatly benefits from the development of advanced diagnostic probes. Here we introduce a 22-nm spaser (plasmonic nanolaser) with the ability to serve as a super-bright, water-soluble, biocompatible probe capable of generating stimulated emission directly inside living cells and animal tissues. We have demonstrated a lasing regime associated with the formation of a dynamic vapour nanobubble around the spaser that leads to giant spasing with emission intensity and spectral width >100 times brighter and 30-fold narrower, respectively, than for quantum dots. The absorption losses in the spaser enhance its multifunctionality, allowing for nanobubble-amplified photothermal and photoacoustic imaging and therapy. Furthermore, the silica spaser surface has been covalently functionalized with folic acid for molecular targeting of cancer cells. All these properties make a nanobubble spaser a promising multimodal, super-contrast, ultrafast cellular probe with a single-pulse nanosecond excitation for a variety of in vitro and in vivo biomedical applications.
Ключевые слова:	CELLS; PARTICLES;
Издано:	2017
Физ. характеристика:	15528