Инд. авторы:	Voropaeva O.F., Senotrusova S.D., Shokin Y.I.
Заглавие:	Numerical investigation of diagnostic properties of p53-dependent microRNAs
Библ. ссылка:	Voropaeva O.F., Senotrusova S.D., Shokin Y.I. Numerical investigation of diagnostic properties of p53-dependent microRNAs // Russian Journal of Numerical Analysis and Mathematical Modelling. - 2017. - Vol.32. - Iss. 3. - P.203-213. - ISSN 0927-6467. - EISSN 1569-3988.
Внешние системы:	DOI: 10.1515/rnam-2017-0018; РИНЦ: 31027524; SCOPUS: 2-s2.0-85021322099; WoS: 000404226400006;
Реферат:	eng: In the present paper we propose a mathematical model and study numerically the functioning of the p53 tumors suppressor protein and the direct positive connection of microRNA molecules related to it. The adequacy of the model is confirmed by qualitative concordance of calculation results with the experimental data concerning transactivation of specific p53-dependent microRNAs. Estimates of stability of individual and p53-mediated properties of microRNA as factors in diagnosing cancer and neurodegenerative diseases are given within the framework of the accepted model. © 2017 Walter de Gruyter GmbH, Berlin/Boston 2017.
Ключевые слова:	Delay differential equations; Calculation results; Tumors; Neurodegenerative diseases; Differential equations; Diagnosis; Computer simulation; tumor marker.; p53; Numerical simulation; Numerical investigations; Transactivation; Tumor markers; RNA; MicroRNAs; delay differential equation; Mdm2; microRNA; Mdm2;
Издано:	2017
Физ. характеристика:	с.203-213
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