Инд. авторы:	Ogienko A.G., Drebushchak V.A., Bogdanova E.G., Yunoshev A.S., Ogienko A.A., Boldyreva E.V., Manakov A.Y.
Заглавие:	Thermodynamic aspects of freeze-drying: A case study of an “organic solvent–water” system
Библ. ссылка:	Ogienko A.G., Drebushchak V.A., Bogdanova E.G., Yunoshev A.S., Ogienko A.A., Boldyreva E.V., Manakov A.Y. Thermodynamic aspects of freeze-drying: A case study of an “organic solvent–water” system // Journal of Thermal Analysis and Calorimetry. - 2017. - Vol.127. - Iss. 2. - P.1593-1604. - ISSN 1388-6150. - EISSN 1572-8943.
Внешние системы:	DOI: 10.1007/s10973-016-6003-8; РИНЦ: 29466588; SCOPUS: 2-s2.0-85006486804; WoS: 000394142200045;
Реферат:	eng: Aqueous solutions of glycine and tetrahydrofuran (THF) were frozen under variable conditions and subsequently annealed. The phases that resulted from this process were studied by X-ray diffraction, DSC and cryotemperature SEM. Under conditions achieved in common laboratory freeze-dryers, the THF clathrate hydrate of cubic structure II was formed in near-quantitative yields. The temperature–composition state diagram for the THF–water–β-glycine systems suggests that the critical temperature of the primary drying stage is the temperature of the four-phase peritectic reaction (269 K), and not the temperature of the congruent melting of the THF hydrate in the THF–water system (278 K). Freeze-drying is shown to go much faster if aqueous solutions are substituted for THF–water solutions. This finding is of great importance for practical applications, including pharmaceutical drug formulation. © 2016, Akadémiai Kiadó, Budapest, Hungary.
Ключевые слова:	Variable conditions; Thermodynamic aspects; Quantitative yields; Pharmaceutical drug formulations; Peritectic reaction; Freeze drying; Critical temperatures; Clathrate hydrate; X ray diffraction; Temperature; Solutions; Low temperature drying; Hydration; Hydrates; Drying; Amino acids; X-ray diffraction; Phase diagram; Freeze-drying; DSC; Cryotemperature SEM; Phase diagrams; Organic solvents;
Издано:	2017
Физ. характеристика:	с.1593-1604
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