Инд. авторы:	Drebushchak V.A., McGregor L., Rychkov D.A.
Заглавие:	Cooling rate “window” in the crystallization of metacetamol form II
Библ. ссылка:	Drebushchak V.A., McGregor L., Rychkov D.A. Cooling rate “window” in the crystallization of metacetamol form II // Journal of Thermal Analysis and Calorimetry. - 2017. - Vol.127. - Iss. 2. - P.1807-1814. - ISSN 1388-6150. - EISSN 1572-8943.
Внешние системы:	DOI: 10.1007/s10973-016-5954-0; РИНЦ: 29467387; SCOPUS: 2-s2.0-84996526161; WoS: 000394142200066;
Реферат:	eng: Melting and crystallization of metacetamol (C8H9NO2, N-(3-hydroxyphenyl)acetamide, structural isomer of paracetamol) were measured using DSC cycling heating–cooling between room temperature and 165 °C with constant heating rate of 6 °C min−1 and variable cooling rate ranging from 3 to 24 °C min−1. The selection of the cooling rate allows us to control the crystallization of metacetamol into one of its two polymorphs, I or II. Pure form II of metacetamol (recently discovered) is crystallized after the cooling rate of 6 °C min−1. Increase or decrease in the cooling rate suppresses the crystallization of the form II and produces the form I with remnant amorphous phase and a small impurity of the form II. The melting points and enthalpies of fusion are 420 K and 26.0 ± 1.3 kJ mol−1 for the form I and 399 K and 21.3 ± 1.1 kJ mol−1 for the form II, respectively. © 2016, Akadémiai Kiadó, Budapest, Hungary.
Ключевые слова:	Variable cooling; Structural isomers; Paracetamol; Metacetamol; Melting and crystallization; Cycling heating; Cooling rates; Polymorphism; Melting; Polymorphism; Metacetamol; DSC; Cooling rate; Amorphous phase; Cooling;
Издано:	2017
Физ. характеристика:	с.1807-1814
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