| Инд. авторы: | Lisachev P.D., Pustylnyak V.O., Shtark M.B. |
| Заглавие: | Sirt1 Regulates p53 Stability and Expression of Its Target S100B during Long-Term Potentiation in Rat Hippocampus |
| Библ. ссылка: | Lisachev P.D., Pustylnyak V.O., Shtark M.B. Sirt1 Regulates p53 Stability and Expression of Its Target S100B during Long-Term Potentiation in Rat Hippocampus // Bulletin of Experimental Biology and Medicine. - 2016. - Vol.160. - Iss. 4. - P.432-434. - ISSN 0007-4888. - EISSN 1573-8221. |
| Внешние системы: | DOI: 10.1007/s10517-016-3189-5; SCOPUS: 2-s2.0-84959105238; |
| Реферат: | eng: Induction of long-term potentiation in rat hippocampus was followed by short-term activation of transcription factor p53 and its subsequent degradation. We studied the effects of EX-527 (inhibitor of deacetylase Sirt1, a negative regulator of p53) and pifi thrin-β (inhibitor of p53-dependent transcription) on the levels of p53 protein and mRNA of its target gene S100B during long-term potentiation. Pifi thrin-β limited the increase in S100B mRNA content after tetanization, which confi rmed signifi cant contribution of p53 in the regulation of S100B during long-term potentiation. EX-527 completely prevented p53 degradation and increased S100B expression induced by tetanization. Thus, Str1 regulates stability of p53 and expression of its target gene S100B in rat hippocampus during long-term potentiation. © 2016, Springer Science+Business Media New York.
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| Ключевые слова: | Sirt1; pifi thrin-β; p53; long-term potentiation; EX-527; |
| Издано: | 2016 |
| Физ. характеристика: | с.432-434 |