Инд. авторы:	Соколова О.О., Штарк М.Б., Лисачев П.Д.
Заглавие:	Нейрональная пластичность и экспрессия генов
Библ. ссылка:	Соколова О.О., Штарк М.Б., Лисачев П.Д. Нейрональная пластичность и экспрессия генов // Успехи физиологических наук. - 2010. - Т.41. - № 1. - С.26-44. - ISSN 0301-1798.
Внешние системы:	РИНЦ: 13797826;
Реферат:	eng: Neuronal plasticity - a fundamental feature of brain - provides adequate interactions with dynamic environment. One of the most deeply investigated forms of the neuronal plasticity is a long-term potentiation (LTP) - a phenomenon underlying learning and memory. Signal paths activated during LTP converge into the nuclear of the neuron, giving rise to launch of the molecular-genetic programs, which mediate structural and functional remodeling of synapses. In the review data concerning involvement of multilevel gene expression into plastic change under neuronal activation are summarized rus: Нейрональная пластичность - фундаментальное свойство мозга, обеспечивающее адекватное взаимодействие организма с динамической окружающей средой. Одной из наиболее глубоко исследованных форм нейрональной пластичности является длительная посттетаническая потенциация (ДВП) - феномен, лежащий в основе обучения и памяти. Активированные в процессе ДВП сигнальные пути конвергируют в ядре нейрона, что приводит к запуску молекулярно-генетических программ, обусловливающих структурные и функциональные изменения синапсов. В обзоре на примере ДВП обобщены данные о вовлечении многоуровневой экспрессии генов в пластические перестройки при нейрональной активации.
Издано:	2010
Физ. характеристика:	с.26-44
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