Инд. авторы:	Grishin O.V., Basalaeva S.V., Umantseva N.D., Ustyuzhaninova N.V., Grishin V.G., Mitrofanov I.M.
Заглавие:	An increased carbon dioxide production in transient hypoxia in healthy subjects at rest
Библ. ссылка:	Grishin O.V., Basalaeva S.V., Umantseva N.D., Ustyuzhaninova N.V., Grishin V.G., Mitrofanov I.M. An increased carbon dioxide production in transient hypoxia in healthy subjects at rest // Human Physiology. - 2011. - Vol.37. - Iss. 5. - P.582-587. - ISSN 0362-1197. - EISSN 1608-3164.
Внешние системы:	DOI: 10.1134/S0362119711040086; РИНЦ: 18007949; SCOPUS: 2-s2.0-80053463345;
Реферат:	eng: Indices of pulmonary gas exchange and heart rate (HR) have been measured in 24 healthy subjects not adapted to hypoxia after hypoxic aerial mixture (HAM) (17, 15, 13 vol % of oxygen) respiration for 15 min. Using group data analysis, it has been shown that hypoxia under the conditions of inhalation of 17 and 15 vol % of O2 caused no significant changes. Hypoxia under the conditions of 13 vol % of O2 inhalation is a threshold one, when ventilation (SpO2) drops below 85%. A significant increase in the lung ventilation (Ve) (10-14%, p < 0. 05) and HR (11-15%, p < 0. 05) have been observed in this case. Hyperpnea was accompanied by an increase in the oxygen uptake rate by 10% and carbon dioxide release rate (10-18%, p < 0. 05). On the contrary, individual data analysis showed changes in the pulmonary gas exchange indices in 90% of subjects in the case of inhalation of 17 vol % of O2 HAM. Four response types have been found: ventilation (increase in lung ventilation), hypoxic hypometabolism (decrease in oxygen consumption rate), and mobilization response (increase in oxygen utilization in the lungs), and anaerobic response, which is expressed in an increase in the carbon dioxide release rate along with an increase in the respiratory quotient. All these responses are of an individual type, but the ventilation response is developed in response to hypoxia caused by inhalation of 13 vol % of O2 HAM and a decrease in SpO2 below 85% in more than 60% of cases. © 2011 Pleiades Publishing, Ltd.
Ключевые слова:	pulmonary gas exchange; hypoxia; anaerobic metabolism;
Издано:	2011
Физ. характеристика:	с.582-587