Инд. авторы:	Проскура А.Л., Малахин И.А., Турнаев И.И., Суслов В.В., Запара Т.А., Ратушняк А.С.
Заглавие:	Межмолекулярные взаимодействия в функциональных системах нейрона
Библ. ссылка:	Проскура А.Л., Малахин И.А., Турнаев И.И., Суслов В.В., Запара Т.А., Ратушняк А.С. Межмолекулярные взаимодействия в функциональных системах нейрона // Вавиловский журнал генетики и селекции. - 2013. - Т.17. - № 4-1. - С.620-628. - ISSN 2500-0462. - EISSN 2500-3259.
Внешние системы:	РИНЦ: 21150791;
Реферат:	rus: Синаптические нейрональные контакты являются одним из основных элементов, обеспечивающих пластичность нервной системы, а изменение эффективности синаптической передачи ответственно за такие реакции, как восприятие, проведение возбуждения, обучение и память. Дендритные шипики представляют постсинаптическую часть возбуждающих синапсов высших отделов мозга млекопитающих. Белок-белковые сети микродоменов шипиков формируют функциональную систему синапсов нейрона. Проведена реконструкция концептуальной модели межмолекулярных взаимодействий, обеспечивающих изменение эффективности синаптической передачи вслед за активацией синапса, интеграцию возбуждения в локальной дендритной сети нейрона и длительное поддержание нового уровня нейротрансмиссии. eng: Neuronal synaptic contacts are among the basic elements that determine the plasticity of the nervous system. Changes in the efficiency of synaptic transmission mediate sensation, conduction of excitation, learning, and memory. Dendritic spines are the postsynaptic part of excitatory synapses in higher divisions of mammalian brains. Protein–protein networks of spine microdomains form the functional system of neuronal synapses. Reconstruction of the conceptual model of molecular interactions has been performed. The model represents activity-dependent changes of the synaptic transmission efficiency, integration of excitation in the local dendritic network of a neuron, and prolonged maintenance of the new level of neurotransmission.
Ключевые слова:	долговременная потенциация; синаптическая пластичность; glutamate receptors; long-term potentiation; synaptic plasticity; глутаматные рецепторы;
Издано:	2013
Физ. характеристика:	с.620-628
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