Инд. авторы:	Проскура А.Л., Вечкапова С.О., Запара Т.А., Ратушняк А.С.
Заглавие:	Реконструкция молекулярного интерактома в системе глутаматных синапсов
Библ. ссылка:	Проскура А.Л., Вечкапова С.О., Запара Т.А., Ратушняк А.С. Реконструкция молекулярного интерактома в системе глутаматных синапсов // Вавиловский журнал генетики и селекции. - 2014. - Т.18. - № 4-3. - С.1205-1218. - ISSN 2500-0462. - EISSN 2500-3259.
Внешние системы:	РИНЦ: 23001150;
Реферат:	rus: Субъединичный состав ионотропных глутаматергических рецепторов играет важную роль в функционировании синапсов. НМДА рецепторы опосредуют быструю возбуждающую нейропередачу и способны конвертировать специфические паттерны нейрональной активности в долговременные изменения синаптической структуры и функций. Основные функциональные свойства (ионная проводимость, чувствительность к глутамату и агонистам, ионам магния, время деактивации), пространственное расположение, закрепление на мембране, чувствительность к фармакологическим агентам определяются их субъединичной композицией. Исследование системы межбелковых взаимодействий в макрокомплексах субъединиц НМДА рецепторов является актуальной задачей. Ее решение позволит приблизиться к пониманию принципов и молекулярных механизмов реализации основных функций нейронов, механизмов развития патологических состояний, поиску фармакологических и терапевтических мишеней их коррекции. Целью работы явилось проанализировать и реконструировать белок-белковые взаимодействия субъединиц НМДА рецепторов, которые обеспечивают их подвижность и закрепление на синаптической мембране, а также функциональную роль в процессах изменения и поддержания эффективности синаптической передачи в гиппокампе. Выделено три группы белков. Они обеспечивают формирование макрокомплексов НМДА рецепторов в глутаматергических синапсах гиппокампа. Белки разнесены на группы по их функции в комплексах на основании информации из различных баз данных, научных статей, в которых охарактеризованы структура гена и белка, экспрессия в мозге, их роль в процессах синаптической пластичности. Особое внимание уделялось белкам, для которых установлена связь с различными когнитивными нарушениями. eng: The subunit composition of ionotropic glutamate receptors plays a significant role in synapse functioning. NMDA receptors mediate fast excitatory neurotransmission. They can convert specific patterns of neuronal activity to long-term changes of the synaptic structure and functions. The main functional properties (ionic conductivity, sensitivity to glutamate and agonists, sensitivity to magnesium ions, and deactivation time), spatial location, anchoring on the membrane, and sensitivity to pharmacological agents are defined by their subunit composition. The investigation of the protein-protein interaction system in macrocomplexes of NMDA receptor subunits is an urgent task. Its solution will shed light on the principles and molecular mechanisms that implement the main functions of a neuron and on mechanisms of disorder development. It will be helpful in the search for pharmacological and therapeutic targets for their corrections. The aim of this investigation is to analyze and reconstruct the protein-protein interactions of NMDA receptor subunits that support their mobility and anchoring on the synaptic membrane, as well as their role in the processes of modulation and support of synaptic transmission efficiency in the hippocampus. Three groups of proteins have been recognized. They support the formation of macrocomplexes of NMDA receptors in the glutamatergic synapses of the hippocampus. Proteins are divided into groups according to their functions in complexes. The division is based on information from different databases and scientific articles where the structures of genes and proteins, expression in the brain, and roles in the processes of synaptic plasticity are described. Special attention is focused on proteins for which associations with various cognitive disorders have been established.
Ключевые слова:	глутаматные рецепторы; synaptic plasticity; glutamate receptors; Macrocomplexes; макрокомплексы; синаптическая пластичность;
Издано:	2014
Физ. характеристика:	с.1205-1218
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