| Инд. авторы: | Seryotkin Y.V., Drebushchak T.N., Boldyreva E.V. |
| Заглавие: | A high-pressure polymorph of chlorpropamide formed on hydrostatic compression of the α-form in saturated ethanol solution |
| Библ. ссылка: | Seryotkin Y.V., Drebushchak T.N., Boldyreva E.V. A high-pressure polymorph of chlorpropamide formed on hydrostatic compression of the α-form in saturated ethanol solution // Acta Crystallographica. Section B: Structural Science. - 2013. - Vol.69. - Iss. 1. - P.77-85. - ISSN 0108-7681. - EISSN 1600-5740. |
| Внешние системы: | DOI: 10.1107/S0108768112051142; PubMed: 23364463; SCOPUS: 2-s2.0-84873821101; |
| Реферат: | eng: The crystal structure of the high-pressure polymorph (α) of an antidiabetic drug, chlorpropamide [4-chloro-N-(propylaminocarbonyl) benzenesulfonamide, C10H13ClN2O3S], which is formed at ∼ 2.8 14;GPa from the α-polymorph (P2 12121) on hydrostatic compression in saturated ethanol solution, has been determined. As a result of the phase transition, the a, c and α parameters change jumpwise, whereas the changes in b parameter are continuous through the phase transition point. The high-pressure form is monoclinic (P2111) and has Z′ equal to 2, the two independent molecules differing in their conformations. The hydrogen bonds expand slightly in the high-pressure polymorph after the transition, and this expansion is interrelated with the changes in molecular conformations enabling a denser packing. The transition is reversible, but the crystal quality deteriorates as a result of multiple compression-decompression cycles, and a pseudomerohedral twinning accompanies the transformation. © 2013 International Union of Crystallography Printed in Singapore-all rights reserved.
|
| Ключевые слова: | high pressure; hydrogen bonds; molecular conformations; polymorphism; twinning; Antidiabetic drug; B-parameter; chlorpropamide; Crystal qualities; Denser packings; Ethanol solutions; High pressure; High-pressure form; High-pressure polymorph; Hydrostatic compression; hyperbarism; molecular conformations; phase transition; polymorphism; pressure; solution and solubility; twin pregnancy; chlorpropamide; high pressure; hydrogen bonds; molecular conformations; polymorphism; twinning; Chlorpropamide; Sulfonamides; Solutions; Propylamines; Pressure; Phase Transition; Molecular Structure; Hydrogen Bonding; Ethanol; Crystallization; hydrogen bonds; hydrogen bond; crystallization; chemistry; chemical structure; article; sulfonamide; propylamine; chlorpropamide; alcohol; 4-chloro-N-(propylaminocarbonyl)benzenesulfonamide; 4 chloro N (propylaminocarbonyl)benzenesulfonamide; Conformations; Twinning; Polymorphism; Hydrogen bonds; Hydrodynamics; Hydraulics; Ethanol; Pseudo-merohedral twinning; Phase transition point; chlorpropamide; Molecular conformation; |
| Издано: | 2013 |
| Физ. характеристика: | с.77-85 |