Инд. авторы:	Seryotkin Y.V., Drebushchak T.N., Boldyreva E.V.
Заглавие:	A high-pressure polymorph of chlorpropamide formed on hydrostatic compression of the α-form in saturated ethanol solution
Библ. ссылка:	Seryotkin Y.V., Drebushchak T.N., Boldyreva E.V. A high-pressure polymorph of chlorpropamide formed on hydrostatic compression of the α-form in saturated ethanol solution // Acta Crystallographica Section B: Structural Science, Crystal Engineering and Materials. - 2013. - Vol.69. - Iss. 1. - P.77-85. - ISSN 2052-5206. - EISSN 2052-5192.
Внешние системы:	DOI: 10.1107/S2052519212051147; SCOPUS: 2-s2.0-84883001089;
Реферат:	eng: The crystal structure of the high-pressure polymorph (α') of an antidiabetic drug, chlorpropamide [4-chloro-N-(propylaminocarbonyl) benzenesulfonamide, C10H13ClN2O3S], which is formed at ∼ 2.8 GPa from the α-polymorph (P2 12121) on hydrostatic compression in saturated ethanol solution, has been determined. As a result of the phase transition, the a, c and α parameters change jumpwise, whereas the changes in b parameter are continuous through the phase transition point. The high-pressure form is monoclinic (P2111) and has Z' equal to 2, the two independent molecules differing in their conformations. The hydrogen bonds expand slightly in the high-pressure polymorph after the transition, and this expansion is interrelated with the changes in molecular conformations enabling a denser packing. The transition is reversible, but the crystal quality deteriorates as a result of multiple compression-decompression cycles, and a pseudomerohedral twinning accompanies the transformation. © 2013.
Ключевые слова:	Chlorpropamide; High pressure; High-pressure polymorph; Hydrostatic compression; Molecular conformation; Phase transition point; Pseudo-merohedral twinning; Ethanol; Hydraulics; Hydrogen bonds; Polymorphism; Twinning; Conformations; Twinning; Polymorphism; molecular conformations; Hydrogen bonds; High pressure; Anti-Diabetic Drugs; Chlorpropamide;
Издано:	2013
Физ. характеристика:	с.77-85